Etomoxir
Etomoxir is a cell-permeable, irreversible, and stereospecific compound. Etomoxir is shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells at a concentration of 1-80 μM and 40 μM, respectively.
| Storage | Store at -20°C |
| M.Wt | 326.82 |
| Cas No. | 124083-20-1 |
| Formula | C17H23ClO4 |
| Synonyms | R-(+)-Etomoxir,Etomoxir |
| Solubility | ≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming |
| Chemical Name | ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | CCOC(=O)C1(CO1)CCCCCCOC2=CC=C(C=C2)Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Rat heart H9c2 myoblastic cells |
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Preparation method |
This compound is soluble in DMSO. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
1-80 μM; 2 h |
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Applications |
In rat heart H9c2 myoblastic cells, Etomoxir concentration-dependently reduced [1-14C]oleic acid incorporation into phosphatidylglycerol (PtdGro) and cardiolipin (CL). In contrast, etomoxir increased [1,3-3H]glycerol incorporation into CL. |
| Animal experiment [2]: | |
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Animal models |
Experimental autoimmune encephalomyelitis (EAE) mice model |
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Dosage form |
15 mg/kg i.p.; days 8 and 15 |
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Application |
In experimental autoimmune encephalomyelitis (EAE) mice, Etomoxir reduced disease severity and the inflammatory response. Etomoxir-treated mice displayed a reduced immune cell infiltration in the CNS with few macrophages, activated microglia, or T cells present. Etomoxir also reduced inflammation and demyelination in the CNS. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Xu FY1, Taylor WA, Hurd JA, et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 2003 Feb;44(2):415-23. Epub 2002 Nov 4. [2] Shriver LP1, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Sci Rep. 2011;1:79. | |
Quality Control & MSDS
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Chemical structure
