Dynamin inhibitory peptide
Dynamin inhibitory peptide (CAS: 251634-21-6) is a peptide-based inhibitor targeting the GTPase dynamin. It is designed to competitively block the interaction between dynamin and amphiphysin proteins, thereby inhibiting dynamin-dependent internalization pathways. Dynamin inhibitory peptide exerts its biological activity primarily by disrupting dynamin–amphiphysin binding. This mechanism effectively inhibits endocytic processes and reduces receptor internalization, including the cellular uptake of GABA receptors in neuronal models. Based on these pharmacological properties, Dynamin inhibitory peptide holds research potential in the study of vesicle trafficking, inhibition of endocytic pathways, and modulation of receptor internalization.
References:
1. McNiven, M. A., Cao, H., Pitts, K. R. & Yoon, Y. (2000) Trends Biochem. Sci. 25, 115–120.
2. Hinshaw, J. E. (2000) Annu. Rev. Cell Dev. Biol 16, 483–519.
3. Thoms S, Erdmann R (Oct 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.". FEBS J 272 (20): 5169–81.
4. Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419-25.
5. Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972-7. 6. Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302-7.
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 1121.26 |
| Cas No. | 251634-21-6 |
| Formula | C47H80N18O14 |
| Synonyms | Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro |
| Solubility | ≥112.1 mg/mL in DMSO; ≥23.6 mg/mL in EtOH; ≥9.4 mg/mL in H2O |
| Chemical Name | Dynamin inhibitory peptide |
| SDF | Download SDF |
| Canonical SMILES | CC(C)C(C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)N2CCCC2C(=O)NC(CC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C(CCC(=O)N)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
