Angiotensin III (human, mouse)
Angiotensin III (human, mouse) (CAS: 13602-53-4) is a hexapeptide (Arg-Val-Tyr-Ile-His-Pro-Phe) produced by N-terminal cleavage of angiotensin II via angiotensinase activity in erythrocytes and tissues. Within the renin-angiotensin-aldosterone system (RAAS), angiotensin III mediates approximately 40% of the pressor activity of angiotensin II, but retains full aldosterone-stimulating capability. Experimental studies reveal that exogenous angiotensin III induces aldosterone secretion and suppresses renin release, paralleling the effects of angiotensin II. Additionally, in rodent brain models, angiotensin III elicits pressor and dipsogenic responses. Angiotensin III interacts with both AT1 and AT2 receptor subtypes, with relative specificity for AT2. This peptide serves as a valuable tool to elucidate RAAS function and receptor signaling in cardiovascular and neuroendocrine research.
References:
1. Blair-West, JR. et al. (1980) J. Endocrinol. 87, 409.
2. Fei, DTW. et al. (1980) Life Sci. 27, 1495.
3. Fink, GD. et al. (1985) Am. J. Physiol. Endocrinol. Metab. 249, E201.
4. Wright, JW. et al. (2011) Prog. Neurobiol. 95, 49.
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 931.09 |
| Cas No. | 13602-53-4 |
| Formula | C46H66N12O9 |
| Synonyms | Arg-Val-Tyr-Ile-His-Pro-Phe |
| Solubility | ≥23.2 mg/mL in H2O; ≥43.8 mg/mL in EtOH; ≥93.1 mg/mL in DMSO |
| Chemical Name | Angiotensin III (human, mouse) |
| SDF | Download SDF |
| Canonical SMILES | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
