| Angiotensin I (human, mouse, rat)Precursor of angiotensin II |
Sample solution is provided at 25 µL, 10mM.
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Quality Control & MSDS
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Chemical structure
Angiotensin I (human, mouse, rat) Dilution Calculator
Angiotensin I (human, mouse, rat) Molarity Calculator
| Cas No. | 484-42-4 | SDF | Download SDF |
| Synonyms | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu | ||
| Chemical Name | Angiotensin I (human, mouse, rat) | ||
| Canonical SMILES | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N | ||
| Formula | C62H89N17O14 | M.Wt | 1296.5 |
| Solubility | Soluble to 1 mg/ml in sterile water | Storage | Desiccate at -20°C |
| General tips | N/A | ||
| Shipping Condition | N/A | ||
Angiotensin I (Ang I) (C62H89N17O14), with the sequence H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH, is formed by the action of renin on angiotensinogen. Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure (<90mmHg systolic blood pressure) at the juxtaglomerular cells. Ang I appears to have no biological activity and exists solely as a precursor to angiotensin II (A II). Ang I is cleaved to Ang II by the angiotensin-converting enzyme (ACE). Ang II increases blood pressure by stimulating the Gq protein in vascular smooth muscle cells (which in turn activates contraction by an IP3-dependent mechanism).
Ref:
1. Lundequist, A. et al. J. Biol. Chem. 279, 32339 (2004); Olson, S. et al. Am. J. Physiol. Lung. Cell Mol. Physiol. 287, L559 (2004); Sanker, S. et al. J. Biol. Chem. 272, 2963 (1997).
2. Preston RA, Materson BJ, Reda DJ, et al. Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy. JAMA. 1998;280(13):1168-1172. doi:10.1001/jama.280.13.1168.
