Angiotensin I (human, mouse, rat)
Angiotensin I (Ang I) (C62H89N17O14), with the sequence H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH, is formed by the action of renin on angiotensinogen. Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure (<90mmHg systolic blood pressure) at the juxtaglomerular cells. Ang I appears to have no biological activity and exists solely as a precursor to angiotensin II (A II). Ang I is cleaved to Ang II by the angiotensin-converting enzyme (ACE). Ang II increases blood pressure by stimulating the Gq protein in vascular smooth muscle cells (which in turn activates contraction by an IP3-dependent mechanism).
Ref:
1. Lundequist, A. et al. J. Biol. Chem. 279, 32339 (2004); Olson, S. et al. Am. J. Physiol. Lung. Cell Mol. Physiol. 287, L559 (2004); Sanker, S. et al. J. Biol. Chem. 272, 2963 (1997).
2. Preston RA, Materson BJ, Reda DJ, et al. Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy. JAMA. 1998;280(13):1168-1172. doi:10.1001/jama.280.13.1168.
- 1. Pengjie Zhang, Bin Du, et al. "Identification and Removal of Pollen Spectral Interference in the Classification of Hazardous Substances Based on Excitation Emission Matrix Fluorescence Spectroscopy" Molecules. 2024 Jul 1;29(13):3132 PMID: 38999084
- 2. Jiwei Xu, Jianjie Xu, et al. "Impact of different classification schemes on discrimination of proteins with noise-contaminated spectra using laboratory-measured fluorescence data." Spectrochim Acta A Mol Biomol Spectrosc. 2023 Aug 5:296:122646. PMID: 37003145
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 1296.5 |
| Cas No. | 484-42-4 |
| Formula | C62H89N17O14 |
| Synonyms | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu |
| Solubility | ≥129.6 mg/mL in DMSO; ≥124.2 mg/mL in H2O; ≥9.16 mg/mL in EtOH |
| Chemical Name | Angiotensin I (human, mouse, rat) |
| SDF | Download SDF |
| Canonical SMILES | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment:[1] | |
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Animal models |
Time-dated pregnant ewes (gestational day 125 ± 5, term ~ 145 days) |
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Dosage form |
5 μg/kg Intracerebroventricular injection |
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Applications |
Intracerebroventricular injection of Ang I significantly increased fetal blood pressure and c-fos expression in the supraoptic nuclei (SON) and the paraventricular nuclei (PVN) in the hypothalamus, accompanied by an increase of fetal plasma arginine vasopressin (AVP). Double labeling experiments showed colocalization of AT1 receptor and c-fos expression in both SON and PVN following Ang I treatment. The results indicate that central angiotensin I increases fetal AVP neuron activity and pressor responses. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Shi L, Mao C, Zeng F, et al. Central angiotensin I increases fetal AVP neuron activity and pressor responses. American Journal of Physiology - Endocrinology and Metabolism, 2010, 298(6): E1274-1282. |
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Chemical structure
