2-Thio-UTP
Catalog No.
B7984
Base modified ribonucleoside triphosphates
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2-Thio-UTP is a base-modified ribonucleoside triphosphate commonly used in RNA-based biomedical research. Incorporation of 2-Thio-UTP into RNA transcripts reduces innate immune activation compared to unmodified RNA. Mechanistically, RNAs transcribed with 2-Thio-UTP lack the ability to activate RNA-dependent protein kinase (PKR), markedly diminish 2'-5'-oligoadenylate synthetase (OAS) pathway induction, decrease recognition by retinoic acid-inducible gene I (RIG-I), and suppress Toll-like receptor (TLR) mediated signaling. Thus, 2-Thio-UTP serves as a research tool in studies designing low-immunogenic RNAs for therapeutic applications.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 500.2 (free acid) |
| Formula | C9H15N2O14P3S (free acid) |
| Synonyms | 2-Thiouridine-5'-Triphosphate |
| Chemical Name | lithium (3,4-dihydroxy-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | O=C(C=CN1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=S.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = ≥95% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
