17-ODYA
Catalog No.
B6373
LTB4 ω-hydroxylase inhibitor
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17-ODYA (CAS: 34450-18-5) is a selective inhibitor of cytochrome P450 fatty acid ω-hydroxylase, an enzyme responsible for ω-hydroxylation reactions involved in steroid, cholesterol, and lipid metabolism. By blocking ω-hydroxylation, 17-ODYA reduces formation of bioactive lipid mediators, such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE). In rat renal cortical microsomes, 17-ODYA inhibits arachidonic acid ω-hydroxylation (IC50 <100 nM), resulting in enhanced sodium excretion and urine output. It also modulates vascular contractility and endothelium-mediated vasorelaxation, making it useful in vascular physiology and inflammation research.
| Physical Appearance | A crystalline solid |
| Storage | Store at RT |
| M.Wt | 280.45 |
| Cas No. | 34450-18-5 |
| Formula | C18H32O2 |
| Solubility | ≥89.8 mg/mL in DMSO; ≥9.84 mg/mL in EtOH |
| Chemical Name | octadec-17-ynoic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(CCCCCCCCCCCCCCCC#C)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
