Poloxin
Catalog No.
A3732
PLK1 inhibitor
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Poloxin (CAS 321688-88-4) is a synthetic small molecule that selectively inhibits the polo-box domain (PBD) of Polo-like kinase 1 (Plk1), a serine/threonine-protein kinase involved in cell division. By targeting the Plk1 PBD, Poloxin interferes with substrate recognition and localization of Plk1, disrupting key mitotic processes. This compound is utilized in biomedical research to investigate Plk1-mediated signaling pathways and to explore the biological consequences of PBD inhibition in cancer cell models, contributing to the understanding of mitotic regulation and the development of potential anticancer strategies.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 297.35 |
| Cas No. | 321688-88-4 |
| Formula | C18H19NO3 |
| Solubility | insoluble in H2O; ≥14.85 mg/mL in DMSO; ≥40.3 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | [(Z)-(2-methyl-4-oxo-5-propan-2-ylcyclohexa-2,5-dien-1-ylidene)amino] 2-methylbenzoate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)C(C(C=C1C)=O)=CC1=NOC(c1c(C)cccc1)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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