|GW843682X PLK1/PLK3 inhibitor,potent and selective|
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||660868-91-7||SDF||Download SDF|
|Solubility||Soluble in DMSO||Storage||Store at -20°C|
|Physical Appearance||Pale yellow solid||Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). GW843682X displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. GW843682X inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.