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GW843682X PLK1/PLK3 inhibitor,potent and selective

Catalog No.A3456
Size Price Stock Qty
5mg
$91.00
In stock
10mg
$143.00
In stock
50mg
$595.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

GW843682X

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Chemical Properties

Cas No. 660868-91-7 SDF Download SDF
Synonyms GW 843682X;GW843682;GW-843682X
Chemical Name 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide
Canonical SMILES COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC
Formula C22H18F3N3O4S M.Wt 477.46
Solubility Soluble in DMSO Storage Store at -20°C
Physical Appearance Pale yellow solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). GW843682X displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. GW843682X inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.