Phytol

Phytol (CAS 150-86-7) is a natural diterpene alcohol derived from chlorophyll metabolism, serving as an activator for retinoid X receptors (RXRs). RXRs are nuclear hormone receptors implicated in transcriptional regulation and cellular differentiation through ligand-dependent signaling pathways mediated by vitamins and hormones. Phytol activates RXRs, displaying Ki values ranging from 2.3 to 67.2 μM. Additionally, phytol interacts with GABA_A receptors, exhibiting sedative and anxiolytic properties, and has been investigated as an antischistosomal candidate in animal models. In mammals, phytol is metabolized to phytanic acid, under the regulation of PPARα.

References:
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