[Nle4,D-Phe7]-α-MSH
Catalog No.
B5363
agonist at melanocortin receptors
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[Nle4,D-Phe7]-α-MSH (CAS No.: 75921-69-6) is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH). As a non-selective melanocortin receptor (MCR) agonist, it can bind to MC1, MC3, MC4, and MC5 receptors, with Ki values of 0.085, 0.4, 3.8, and 5.1 nM, respectively. It mainly promotes melanin production by activating MC1R, thereby inducing skin pigmentation. In in vitro studies, [Nle4,D-Phe7]-α-MSH is approximately 26-fold more active than native α-MSH. This compound is commonly used in research on sunlight-induced skin cancer, melanoma, inflammation, and male erectile dysfunction. In cell and animal models, it is typically administered via subcutaneous or intravenous injection, with the specific dose and concentration depending on the experimental design and research objectives.
| Physical Appearance | White lyophilised solid |
| Storage | Desiccate at -20°C |
| M.Wt | 1646.86 |
| Cas No. | 75921-69-6 |
| Formula | C78H111N21O19 |
| Solubility | ≥107.8 mg/mL in DMSO; ≥7.24 mg/mL in EtOH with ultrasonic; ≥101.2 mg/mL in H2O |
| Chemical Name | (4S,5Z,7S,8Z,10R,11Z,13S,14Z,16S,17Z,20Z,22S)-7-((1H-imidazol-5-yl)methyl)-16-((1H-indol-3-yl)methyl)-26-amino-10-benzyl-4-((Z)-((2S,3Z,5S,6Z,8S,9Z,11S,12Z)-2-butyl-1,4,7,10,13-pentahydroxy-8-(4-hydroxybenzyl)-5,11-bis(hydroxymethyl)-3,6,9,12-tetraazatetr |
| SDF | Download SDF |
| Canonical SMILES | CCCC[C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C)([H])CO)([H])CC1=CC=C(O)C=C1)([H])CO)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](C(N2CCC[C@@]2([H])/C(O)=N/[C@@](C(O)=N)([H])C(C)C)=O)([H])CCCC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |