A-740003
Catalog No.
A3136
P2X7 receptor antagonist
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A-740003 (CAS: 861393-28-4) is a selective and competitive antagonist targeting the P2X7 receptor, a member of the ATP-gated ionotropic P2X receptor family involved in immune cell signaling, cytokine secretion, apoptosis, and cellular proliferation. The antagonist displays IC50 values of 18 nM and 40 nM against mouse and human P2X7 receptors, respectively. In human THP-1 macrophage-like cells, A-740003 inhibits pore formation assessed by Yo-Pro uptake assay (IC50 = 92 nM) and reduces interleukin-1β secretion (IC50 = 156 nM). This compound is employed in research investigating P2X7-mediated inflammatory pathways and neuropathic pain mechanisms.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 474.57 |
Cas No. | 861393-28-4 |
Formula | C26H30N6O3 |
Synonyms | A 740003;A740003 |
Solubility | ≥23.73 mg/mL in DMSO; insoluble in H2O; ≥2.48 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | N-[1-[(E)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide |
SDF | Download SDF |
Canonical SMILES | CC(C)(C)C(NC(=O)CC1=CC(=C(C=C1)OC)OC)N=C(NC#N)NC2=CC=CC3=C2C=CC=N3 |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Description | A-740003 is potent, selective and competitive antagonist of P2X7 receptor with IC50 values of 18 nM and 40 nM for rat and human receptors, respectively. | |||||
Targets | P2X7 receptor | |||||
IC50 | 18 nM (rat) 40 nM (human) |
Quality Control & MSDS
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Chemical structure
