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Ferrostatin-1 (Fer-1)Ferroptosis inhibitor, erastin-induced

Ferrostatin-1 (Fer-1)

Catalog No. A4371
Size Price Stock Qty
10mM (in 1mL DMSO) $60.00 In stock
5mg $45.00 In stock
25mg $170.00 In stock
100mg $550.00 In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Chemical structure

Ferrostatin-1 (Fer-1)

Biological Activity

Description Ferrostatin-1 is a selective inhibitor of erastin induced ferroptosis with EC50 value of 60 nM.
Targets erastin induced ferroptosis          
IC50 60 nM (EC50)          

Protocol

Cell experiment [1]:

Cell lines

Healthy medium spiny neurons, oligodendrocytes, kidney proximal tubules cell

Preparation method

The solubility of this compound in DMSO is >9.8mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10 nM, 100 nM, and 1 μM

Applications

Fer-1 (10 nM, 100 nM, and 1 μM) significantly increased the number of healthy MSNs. Fer-1 (1 μM) statistically increased the number of healthy MSN. Fer-1 (100 nM) fully protected oligodendrocytes from cystine deprivation. Fer-1 (0.1-2 μM) prevented lethality induced by hydroxyquinoline and ferrous ammonium sulfate (HQ + Fe; 10 μM each).

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Skouta R, Dixon S J, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models[J]. Journal of the American Chemical Society, 2014, 136(12): 4551-4556.

Ferrostatin-1 (Fer-1) Dilution Calculator

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Chemical Properties

Cas No. 347174-05-4 SDF Download SDF
Canonical SMILES NC1=C(NC2CCCCC2)C=CC(C(OCC)=O)=C1
Formula C15H22N2O2 M.Wt 262.35
Solubility >9.8mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Ferrostatin-1 is a selective inhibitor of ferroptosis.

Ferroptosis is a regulated, oxidative, nanapoptotic cell death, Ferrostatin-1 has been founded as a potent inhibitor of it. Fer-1 can attenuate oxidative, iron-dependent cancer cell death through blocking cystine import and glutathione production. It had been reported to prevent Huntington's disease cellular models to death by inhibiting lipid peroxidation.[1]

Reference:
1.  Skouta, R., et al., Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc, 2014. 136(12): p. 4551-6.