|Ferrostatin-1 (Fer-1)Ferroptosis inhibitor, erastin-induced|
Sample solution is provided at 25 µL, 10mM.
Publications citing ApexBio Products
|Description||Ferrostatin-1 is a selective inhibitor of erastin induced ferroptosis with EC50 value of 60 nM.|
|Targets||erastin induced ferroptosis|
|IC50||60 nM (EC50)|
|Cas No.||347174-05-4||SDF||Download SDF|
|Solubility||Soluble in DMSO > 10 mM||Storage||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Ferrostatin-1 is a selective inhibitor of ferroptosis.
Ferroptosis is a regulated, oxidative, nanapoptotic cell death, Ferrostatin-1 has been founded as a potent inhibitor of it. Fer-1 can attenuate oxidative, iron-dependent cancer cell death through blocking cystine import and glutathione production. It had been reported to prevent Huntington's disease cellular models to death by inhibiting lipid peroxidation.
1. Skouta, R., et al., Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc, 2014. 136(12): p. 4551-6.