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Ferrostatin-1 (Fer-1)Ferroptosis inhibitor, erastin-induced

Ferrostatin-1 (Fer-1)

Catalog No. A4371
Size Price Stock Qty
5mg $45.00 In stock
25mg $170.00 In stock
100mg $550.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

Ferrostatin-1 (Fer-1)

Biological Activity

Description Ferrostatin-1 is a selective inhibitor of erastin induced ferroptosis with EC50 value of 60 nM.
Targets erastin induced ferroptosis          
IC50 60 nM (EC50)          

Ferrostatin-1 (Fer-1) Dilution Calculator

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Chemical Properties

Cas No. 347174-05-4 SDF Download SDF
Canonical SMILES NC1=C(NC2CCCCC2)C=CC(C(OCC)=O)=C1
Formula C15H22N2O2 M.Wt 262.35
Solubility Soluble in DMSO > 10 mM Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Ferrostatin-1 is a selective inhibitor of ferroptosis.

Ferroptosis is a regulated, oxidative, nanapoptotic cell death, Ferrostatin-1 has been founded as a potent inhibitor of it. Fer-1 can attenuate oxidative, iron-dependent cancer cell death through blocking cystine import and glutathione production. It had been reported to prevent Huntington's disease cellular models to death by inhibiting lipid peroxidation.[1]

Reference:
1.  Skouta, R., et al., Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc, 2014. 136(12): p. 4551-6.