Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
Z-DEVD-FMK is a tetrapeptide caspase inhibitor that is considered relatively selective for caspase-3 and has been widely used in in vitro and in vivo models of acute injury to delineate roles for caspase 3 in neuronal cell death.
Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Z-IETD-FMK is an inhibitor of caspase 8 .
The broad spectrum caspase inhibitor, Q-VD-OPh, provides a cost effective, non toxic, and highly speciﬁc means of apoptotic inhibition and provides new insight into the design of new inhibitors1.
Cisplatin is a highly effective and broad-spectrum chemotherapeutic agent .
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