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YAP-TEAD Inhibitor 1 (Peptide 17)

Catalog No.
A1149
 
Grouped product items
SizePriceStock Qty
1mg
$160.00
In stock
5mg
$600.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

YAP-TEAD Inhibitor 1 (Peptide 17) is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). It has potential application value in YAP related cancer. 

Reference:

[1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett, 2014, 5(9): 993-8.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt2019.86
FormulaC93H144ClN23O21S2
Solubility≥24.45 mg/mL in DMSO; ≥47.6 mg/mL in EtOH; ≥89.4 mg/mL in H2O
Chemical Name(S)-4-((S)-1-((S)-1-((S)-2-((3S,6S,9S,12R,18S,21S,24S,27S,30S,35aS)-18-((S)-2-((S)-1-((S)-2-acetamido-3-methylbutanoyl)pyrrolidine-2-carboxamido)-3-(3-chlorophenyl)propanamido)-27-(4-aminobutyl)-9-benzyl-30-butyl-24-(3-guanidinopropyl)-6-(hydroxymethyl)-2
SDFDownload SDF
Canonical SMILESO=C([C@H](CCC1)N1C([C@H](CCCC)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC2=CC(Cl)=CC=C2)NC([C@H]3N(C([C@H](C(C)C)NC(C)=O)=O)CCC3)=O)=O)CCSSC[C@@H](C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(N[C@@H](CCC(O)=O)C(N)=O)=O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

YAP-TEAD Inhibitor 1 (Peptide 17)

Related Biological Data

YAP-TEAD Inhibitor 1 (Peptide 17)