Xanthinol Nicotinate

Xanthinol Nicotinate (CAS No.: 437-74-1) is a synthetic small molecule and nicotinic acid derivative that is broadly categorized as a vasoactive metabolic modulator for vascular biology and pharmacology research, with reported activity characterized by relaxation of small arterial and capillary smooth muscle, reduced peripheral vascular resistance, improved hemorheological behavior, and facilitation of transmembrane cellular entry associated with increased glucose utilization and cellular energetic state in experimental systems; in drug discovery workflows it is therefore commonly positioned within microcirculation focused assay panels and mechanism oriented studies of vascular tone and cell metabolism, where its functional background is generally interpreted through combined smooth muscle regulatory processes and nicotinate linked metabolic signaling rather than a single definitively validated molecular target, and where pathway level hypotheses frequently include cyclic nucleotide dependent vasomotor regulation and metabolic stress response networks that can be interrogated using endothelial and vascular smooth muscle cell models as well as exploratory rodent hemodynamic paradigms; because publicly standardized target deconvolution and potency reporting remain limited for this compound, in vitro activity is typically discussed qualitatively as occurring from micromolar to higher micromolar concentration domains depending on assay design, readout modality, and exposure duration, and practical applications include use as a reference or comparator compound in screens for vasoactive or metabolism influencing chemotypes, with the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives, and all use is restricted to controlled laboratory research settings and not for human consumption or any non research application.