Vorasidenib
Catalog No.
BA7847
Vorasidenib (AG-881) is an orally available, brain-permeable, second-generation dual inhibitor of mutant isocitrate dehydrogenase 1 and 2.
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Vorasidenib (AG-881) is an orally available, brain-permeable, second-generation dual inhibitor of mutant isocitrate dehydrogenase 1 and 2.Vorasidenib (AG-881) inhibits D-2-HG nanomolarly, with values for R132C, IDH1R132G, IDH1R132H, and IDH1R132S ranging from 0.04 to 22 nM, values of 7 to 14 nM for R140Q, and 130 nM for R172K.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 414.74 |
| Cas No. | 1644545-52-7 |
| Formula | C14H13ClF6N6 |
| Synonyms | AG-881 |
| Solubility | ≥26.35 mg/mL in DMSO; ≥25.6 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine |
| SDF | Download SDF |
| Canonical SMILES | C[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
