Vinpocetine
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE) with a Ki value of 14±2μM [1].
Vinpocetine has been reported to have a selective and noncompetitive inhibition of Ca2+ PDE and thus regulate cyclic GMP levels in smooth muscle. In addition, vinpocetine has been revealed to inhibit the activities of three resolvable PDE in the cytosol of rat aorta with Ki values of 14±2μM, >1000μM and >1000μM for Ca2+ PDE(+)CaM, cGMP PDE and cAMP PDE, respectively. Apart from these, vinpocetine has shown the potent inhibition of 5-HT-induced contractions in endothelium-intact rat aorta with an EC50 value of 1μM [1].
References:
[1] Souness JE1, Brazdil R, Diocee BK, Jordan R. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine. Br J Pharmacol. 1989 Nov;98(3):725-34.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 350.45 |
| Cas No. | 42971-09-5 |
| Formula | C22H26N2O2 |
| Solubility | ≥2.59 mg/mL in H2O with gentle warming and ultrasonic; ≥2.99 mg/mL in EtOH with ultrasonic; ≥5.83 mg/mL in DMSO |
| Chemical Name | (41S,13aS)-ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | O=C(C(N1C2=C(C3=CC=CC=C13)CC4)=C[C@@]5(CC)[C@H]2N4CCC5)OCC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
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