undecanedioate

undecanedioate (CAS No.: 1852-04-6) is a medium-chain dicarboxylate metabolite associated with extracellular matrix macromolecules, with a particular affinity for elastin, and is widely utilized in biomedical research to investigate matrix remodeling and elastin-associated processes. It has been shown to participate in the regulation of extracellular matrix dynamics, influencing elastin metabolism, conformational organization, and the balance between synthesis and degradation of matrix proteins, thereby contributing to tissue elasticity and structural integrity. Mechanistically, undecanedioate is thought to modulate pathways involved in extracellular matrix turnover and elastin fiber stabilization, making it a useful tool for studying tissue repair, fibrosis, and related pathological conditions. In addition to its structural and regulatory roles, this compound exhibits antifungal activity against dermatophytes such as Trichophyton and Microsporum species at low millimolar concentrations, and has been employed as a chemical building block in the development of proteolysis-targeting chimeras for targeted protein degradation in oncology research, particularly in models of mutant EGFR-expressing cancer cells. Its presence in natural sources and environmental particulate matter further supports its relevance in both physiological and exposure-related studies. In vitro and in vivo applications typically explore its effects across micromolar to millimolar concentration ranges, depending on the experimental context, including cell-based assays of matrix remodeling, elastin metabolism, and drug discovery platforms focused on targeted protein degradation.