UCPH 101

UCPH 101 (CAS No.: 1118460-77-7) is a small-molecule, selective inhibitor of excitatory amino acid transporter subtype 1 (EAAT1), a glial glutamate transporter critically involved in maintaining extracellular glutamate homeostasis in the central nervous system. By inhibiting EAAT1-mediated glutamate uptake, UCPH 101 elevates extracellular glutamate levels and thereby modulates excitatory neurotransmission and synaptic signaling dynamics. The compound exhibits inhibitory activity in the low micromolar range in vitro, with reported potency consistent with effective and selective engagement of EAAT1. Mechanistically, UCPH 101 serves as a valuable pharmacological tool for dissecting the role of glutamate transporters in neurotransmitter clearance, synaptic plasticity, and excitotoxic processes. It is widely applied in cellular and biochemical assays to investigate glutamate transporter function, as well as in experimental models of neurological disorders, including neurodegenerative diseases and brain injury, where dysregulation of glutamate homeostasis is implicated. Experimental concentrations and dosing regimens vary depending on specific assay conditions and research objectives, supporting its use in mechanistic studies and early-stage drug discovery efforts targeting glutamatergic signaling pathways.