UC-514321
UC-514321 is a new type of small molecule compound, which is a structural analogue of NSC370284 but shows higher biological activity. Studies have shown that UC-514321 can effectively target the STAT3/5 signaling pathway and selectively inhibit the expression of the TET1 gene, thereby exerting a significant anti-tumor effect. In both the in vitro cell model and the in vivo animal model of acute myeloid leukemia (AML), UC-514321 demonstrated excellent anti-leukemia activity, effectively inhibiting the proliferation of AML cells and inducing cell apoptosis. Furthermore, UC-514321 demonstrated low toxicity and high safety in animal experiments, suggesting that it has good potential for clinical transformation. Therefore, UC-514321, as an efficient and low-toxicity STAT3/5 inhibitor and TET1 expression regulator, is expected to become a new candidate drug for the treatment of AML.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 441.56 |
| Cas No. | 299420-83-0 |
| Formula | C26H35NO5 |
| Chemical Name | 6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol |
| SDF | Download SDF |
| Canonical SMILES | OC(C=C(OCO1)C1=C2)=C2C(C3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)N4CCOCC4 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
