Tyrphostin AG30 (AG30)

Tyrphostin AG30 (AG30) (CAS No.: 122520-79-0) is a synthetic small-molecule inhibitor belonging to the tyrphostin class of protein tyrosine kinase inhibitors, widely utilized in signal transduction research to interrogate receptor-mediated phosphorylation pathways. It exhibits potent and selective inhibitory activity toward epidermal growth factor receptor (EGFR) tyrosine kinase and related c-ErbB signaling, effectively suppressing c-ErbB-induced cellular self-renewal processes and downstream activation of STAT5 in primary erythroid cells. By modulating these pathways, Tyrphostin AG30 serves as a valuable tool for studying the regulation of cell proliferation, differentiation, and adhesion dynamics governed by receptor tyrosine kinases. Its activity is generally observed in the low micromolar range in cellular systems, consistent with other compounds in the tyrphostin family. In vitro, it is commonly applied in mechanistic studies of oncogenic signaling, erythropoiesis, and kinase-dependent cellular responses, while in vivo or ex vivo experimental usage depends on specific model systems and study design parameters.