Thymalfasin

Thymalfasin (CAS No.: 62304-98-7) is a synthetic thymosin alpha 1 derivative, mainly used to modulate immune system function. Its mechanisms of action include promoting T-cell maturation and differentiation, enhancing the secretion of Th1-type cytokines (such as IL-2 and IFN-γ), thereby improving the body's immune response to viruses and tumor cells. In addition, Thymalfasin can inhibit overly active Th2-type immune responses, correct Th1/Th2 imbalance, and reduce the risk of allergy or autoimmunity. In in vitro studies, Thymalfasin showed growth-inhibitory effects on multiple myeloma cell lines (such as 5TGM1, OPM-2, LP-1, and U266), with activity observable at low micromolar levels. In cell models, Thymalfasin can enhance T-cell proliferation and activation, and promote natural killer (NK) cell activity and dendritic cell (DC) maturation. In animal models, Thymalfasin has been used to evaluate its immunomodulatory effects, with doses or concentrations typically depending on the experimental design and research objectives. In drug screening studies, Thymalfasin has attracted broad attention for its potential as an immunomodulator, especially in the fields of antiviral and antitumor therapy.