Thalidomide-O-amido-C4-NH2 TFA
Catalog No.
A9984
A synthetic E3 ligand-Linker conjugate
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Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthetic E3 ligand-Linker conjugate. It is based on Thalidomide and linked to functional groups via specific linking arms (linkers) to form a molecular tool that can be used in protein degradation technologies such as PROTAC. The compound specifically binds to the Cereblon (CRBN) protein, a key component of the E3 ubiquitin ligase complex, thereby inducing ubiquitination and degradation of the target protein.
| Storage | Store at -20°C for 3 years. |
| M.Wt | 516.43 |
| Cas No. | 1799711-25-3 |
| Formula | C21H23F3N4O8 |
| Solubility | ≥51.7 mg/mL in DMSO; insoluble in EtOH; ≥52.8 mg/mL in H2O |
| Chemical Name | N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 2,2,2-trifluoroacetate |
| SDF | Download SDF |
| Canonical SMILES | O=C(NCCCCN)COC1=C(C(N(C2C(NC(CC2)=O)=O)C3=O)=O)C3=CC=C1.OC(C(F)(F)F)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
