TH34

TH34 (CAS No.: 2196203-96-8) is a selective small-molecule inhibitor of class II histone deacetylases, primarily targeting HDAC6, HDAC8, and HDAC10, with inhibitory activity in the low micromolar range and markedly reduced activity against class I isoforms such as HDAC1, HDAC2, and HDAC3. As an epigenetic modulator, TH34 interferes with acetylation-dependent regulatory pathways that govern chromatin organization, protein stability, and cellular stress responses. In cellular studies, this compound has been shown to induce caspase-dependent programmed cell death in human neuroblastoma cell lines in a concentration-dependent manner, accompanied by DNA damage signaling, while exhibiting minimal effects on non-transformed human cells under comparable conditions. These properties make TH34 a valuable research tool for investigating isoform-selective HDAC inhibition, mechanisms of epigenetic regulation, and the role of HDAC6/8/10 in oncogenic processes and cellular homeostasis. It is commonly utilized in in vitro assays and disease-relevant cell models to explore pathway-specific responses, with experimental concentrations determined by study design and biological context.