Tegoprazan (CJ-12420), a potassium-competitive acid blocker, is a potent, orally active, and highly selective inhibitor of gastric H/K-ATPase, capable of controlling gastric acid secretion and motility, with in vitro assayed values of 0.29-0.52 μM against H/K-ATPase in swine, dogs, and humans.
Chemical Properties
Physical Appearance
A solid
Storage
-20°C
M.Wt
387.38
Cas No.
942195-55-3
Formula
C20H19F2N3O3
Synonyms
CJ-12420;RQ-00000004
Solubility
≥17.63 mg/mL in DMSO with ultrasonic; ≥12.55 mg/mL in EtOH with ultrasonic; insoluble in H2O