Taltirelin
Catalog No.
B3535
novel orally active TRH analogue
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Taltirelin (CAS No.: 103300-74-9) is a thyrotropin-releasing hormone (TRH) analog. As a superagonist of the TRH receptor, it has an IC50 of 910 nM and an EC50 of 36 nM, and can effectively stimulate an increase in intracellular calcium ion concentration. This compound can cross the blood-brain barrier and exhibits good central nervous system activity. In cellular and animal model studies of Parkinson’s disease, Taltirelin shows neuroprotective effects, improving cell viability and reducing apoptosis. In addition, in a mouse model of cancer-related fatigue, Taltirelin can alleviate fatigue-like behavior. The dose or concentration used in experiments typically depends on the experimental design and research objectives.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 405.41 |
| Cas No. | 103300-74-9 |
| Formula | C17H23N7O5 |
| Solubility | Soluble to 50 mM in sterile water |
| Chemical Name | (S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | CN(C(C1)=O)C(O)=N[C@@H]1C(N[C@@H](Cc1cnc[nH]1)C(N(CCC1)[C@@H]1C(N)=O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
