Talarozole
Catalog No.
A3853
Cytochrome P450 inhibitor
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Talarozole (CAS 201410-53-9) is a selective inhibitor of cytochrome P450 enzymes, specifically targeting the metabolism of endogenous all-trans retinoic acid. It achieves potent enzyme inhibition with an IC50 value of 4 nM. Through suppression of retinoic acid degradation, talarozole modulates the gene expression profile in skin tissues, leading to increased mRNA levels of CRABP2, KRT4, CYP26A1, and CYP26B1, and decreased levels of KRT2 and IL-1α. Notably, epidermal thickness and inflammation remain unaffected during topical treatment. Talarozole serves as a valuable research tool and exhibits therapeutic potential for conditions like psoriasis and acne.
| Storage | Store at -20°C |
| M.Wt | 377.51 |
| Cas No. | 201410-53-9 |
| Formula | C21H23N5S |
| Synonyms | Rambazole;R115866;R-115866;R 115866 |
| Solubility | ≥48 mg/mL in DMSO; ≥9.34 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine |
| SDF | Download SDF |
| Canonical SMILES | CCC(CC)C(c(cc1)ccc1Nc1nc(cccc2)c2[s]1)[n]1ncnc1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | Talarozole is a potent and selective inhibitor of cytochrome P450. | |||||
| Targets | cytochrome P450 | |||||
| IC50 | ||||||
Quality Control & MSDS
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Chemical structure
