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Talarozole

Catalog No.
A3853
Cytochrome P450 inhibitor
Grouped product items
SizePriceStock Qty
2mg
$117.00
In stock
5mg
$170.00
In stock
10mg
$235.00
In stock
50mg
$548.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Talarozole (CAS 201410-53-9) is a selective inhibitor of cytochrome P450 enzymes, specifically targeting the metabolism of endogenous all-trans retinoic acid. It achieves potent enzyme inhibition with an IC50 value of 4 nM. Through suppression of retinoic acid degradation, talarozole modulates the gene expression profile in skin tissues, leading to increased mRNA levels of CRABP2, KRT4, CYP26A1, and CYP26B1, and decreased levels of KRT2 and IL-1α. Notably, epidermal thickness and inflammation remain unaffected during topical treatment. Talarozole serves as a valuable research tool and exhibits therapeutic potential for conditions like psoriasis and acne.

Chemical Properties

StorageStore at -20°C
M.Wt377.51
Cas No.201410-53-9
FormulaC21H23N5S
SynonymsRambazole;R115866;R-115866;R 115866
Solubility≥48 mg/mL in DMSO; ≥9.34 mg/mL in EtOH; insoluble in H2O
Chemical NameN-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine
SDFDownload SDF
Canonical SMILESCCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description Talarozole is a potent and selective inhibitor of cytochrome P450.
Targets cytochrome P450          
IC50            

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