SW106065

SW106065 (CAS No.: 62289-81-0) is a small-molecule apoptosis inducer primarily investigated as an anticancer agent for malignant peripheral nerve sheath tumors (MPNST), functioning through disruption of cellular energy homeostasis and induction of programmed cell death. It has been shown to inhibit ATP consumption in sMPNST and related tumor models, with activity observed in the low micromolar range, and to suppress proliferation of human MPNST cell lines such as S462 and SNF96.2 with potency in the nanomolar to submicromolar range. Mechanistically, SW106065 promotes apoptosis and induces cell cycle arrest at both G1/G0 and G2/M phases in patient-derived tumor cells, indicating broad interference with cell cycle regulation and survival pathways. Notably, it demonstrates selectivity toward malignant cells, exhibiting minimal cytotoxicity in normal proliferating Schwann cells and mouse embryonic fibroblasts under comparable conditions. In vivo studies using xenograft mouse models have shown that systemic administration can achieve tumor-penetrant concentrations and significantly reduce tumor growth, supporting its utility in preclinical oncology research. Beyond oncology, SW106065 has also been reported to inhibit replication of certain influenza A virus strains in cell-based assays, suggesting additional utility in antiviral research contexts. This compound is widely applied in studies of tumor biology, apoptosis signaling, and therapeutic screening, with experimental concentrations or dosing regimens varying depending on specific model systems and research objectives.