Sulfosuccinimidyl Oleate (sodium salt)

Sulfosuccinimidyl Oleate (sodium salt) (CAS No.: 1212012-37-7) is a synthetic long-chain fatty acid derivative widely used as a biochemical probe in studies of lipid metabolism, mitochondrial function, and inflammatory signaling. This compound is recognized as a potent and irreversible inhibitor of the mitochondrial respiratory chain, leading to suppression of cellular oxidative metabolism and energy production, and it is also known to inhibit fatty acid transport into cells, thereby modulating lipid uptake and utilization pathways. A key molecular target of sulfosuccinimidyl oleate is the scavenger receptor CD36, to which it binds on the surface of microglial and other cell types, influencing lipid sensing and downstream signaling events associated with inflammation and metabolic regulation. Through CD36 engagement, it has been shown to exert anti-inflammatory effects, making it a useful tool for investigating neuroinflammation, macrophage activation, and metabolic disorders. In vitro, its biological activity is typically observed in the low micromolar range, although effective concentrations vary depending on cell type and assay conditions. In research settings, it is commonly applied in cell-based assays to dissect fatty acid transport mechanisms, mitochondrial dysfunction, and receptor-mediated signaling, as well as in animal models to explore the role of lipid metabolism in disease pathogenesis, with dosing regimens tailored to specific experimental objectives.