Sulfasalazine
Sulfasalazine (599-79-1) is a small-molecule inhibitor targeting the NF-κB signaling pathway and the cystine-glutamate antiporter system (system Xc-). It is designed to suppress NF-κB activation and inhibit cystine uptake, thereby modulating inflammatory gene expression and intracellular glutathione synthesis.
Sulfasalazine exerts its biological activity primarily through inhibition of NF-κB activation and blockade of system Xc-. In in vitro studies, sulfasalazine demonstrates growth inhibition and induction of apoptosis in several cancer cell lines, including MIA PaCa-2, PANC-1, and glioblastoma cells, with reported IC50 values ranging from approximately 0.2 to 0.5 mM depending on cell type and conditions.
Sulfasalazine holds research potential in inflammation, NF-κB signaling, oxidative stress modulation, and cancer studies.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 398.39 |
| Cas No. | 599-79-1 |
| Formula | C18H14N4O5S |
| Solubility | insoluble in ETOH; insoluble in H2O; ≥17.7 mg/mL in DMSO |
| Chemical Name | (3Z)-6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(C(C(C=C1)=O)=CC1=NNc(cc1)ccc1S(Nc1ncccc1)(=O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
