ST271

ST271 (CAS No.: 106392-48-7) is a small-molecule protein tyrosine kinase (PTK) inhibitor widely utilized as a biochemical tool to investigate tyrosine phosphorylation–dependent signaling pathways. It effectively suppresses phospholipase D activation triggered by receptor agonists such as fMet-Leu-Phe and platelet-activating factor, exhibiting inhibitory activity in the low micromolar range, and demonstrates the ability to modulate downstream lipid signaling events. In platelet-related systems, ST271 partially inhibits peptide phosphorylation in membrane preparations and permeabilized cells, and it blocks FcγRII-mediated inositol phosphate formation, indicating interference with receptor-coupled tyrosine kinase signaling. Additionally, modest but significant attenuation of responses to agonists such as thrombin and U46619 has been observed, supporting its role in dissecting signal transduction mechanisms involving kinase-regulated pathways. This compound is commonly applied in in vitro cellular assays and mechanistic studies focused on receptor signaling, phospholipase regulation, and kinase-dependent processes, with experimental concentrations adjusted according to specific model systems and research objectives.