SRT2183

SRT2183 (CAS No.: 1001908-89-9) is a synthetic small-molecule sirtuin modulator that acts as a selective activator of the NAD-dependent deacetylase Sirtuin 1 (SIRT1), and is widely used to dissect epigenetic regulation and signal transduction networks in biochemical and cellular systems, aligning with the needs of biomedical research and drug discovery settings; biochemical assays show that it has submicromolar activation potency in systems using fluorescently labeled substrates, but the results are method-dependent, and orthogonal assays are recommended to confirm target engagement and functional association; at the cellular level, studies have reported that it can induce proliferation inhibition and apoptosis in certain models, accompanied by STAT3 and NF-κB deacetylation and reduced c-Myc protein levels, while in some primary cell contexts it can attenuate oxidative stress-induced apoptosis, reflecting the context dependence determined by SIRT1-regulated transcriptional programs; broad pharmacological profiling suggests that this compound shows activity at micromolar levels against multiple non-targets (including cannabinoid receptor CB1, adenosine receptor A3, and phosphodiesterase 5), and experimental designs should include selectivity controls and counter-screening to ensure specificity; in terms of functional applications, it has been used to study RANKL-driven osteoclastogenesis and bone resorption-related pathways, and as a tool compound in tumor- and inflammation-related signal transduction research; overall, its in vitro activity spans the submicromolar to low micromolar range, making it suitable for pathway elucidation, target validation, and screening paradigms centered on deacetylation regulation, with the experimental concentration or dose typically requiring optimization according to the specific experimental design, readout parameters, and research objectives; For laboratory research use only, not for human or veterinary use.