Sodium aescinate

Sodium aescinate (CAS No.: 20977-05-3) is a bioactive compound classified as a triterpene saponin, primarily extracted from the seeds of Aesculus hippocastanum. It is recognized for its anti-inflammatory and antioxidant properties, making it a valuable subject in biomedical research and drug discovery. The compound exhibits its effects by modulating the CARMA3/NF-κB signaling pathway, thereby inhibiting the growth of hepatocellular carcinoma cells. In vitro activity levels are generally observed within the nanomolar to micromolar range, reflecting its potent biological efficacy. Research often involves various cell and animal models to explore its mechanism of action further, with concentrations tailored to specific experimental designs and objectives. Due to its vasoactive and organ-protective characteristics, sodium aescinate is extensively studied for its potential in various preclinical settings, although it is strictly reserved for research purposes and not for clinical applications, human consumption, or any therapeutic uses.