Sitafloxacin
Sitafloxacin is anantibiotic against gram-positive, gram-negativeand anaerobebacteria[1].
Sitafloxacin is a novel fluoroquinolone antibiotic with a broad antibacterial spectrum. It has activity against Enterobacterial species (gram-positive bacteria) with MIC50 values ranging from 0.008 to 1mg/ml and MIC90 values ranging from 0.015 to 2mg/ml. For the gram-negative bacteria, sitafloxacinis are found to be above eight-fold effective than ciprofloxacin against Acinetobacter spp. with MIC values ranging from 0.008 to 8mg/ml. Besides, sitafloxacinis are reported to inhibit anaerobic bacteria including Bacteroides species, Clostridium perfringens and Peptostreptococcus spp. with the MIC50 values ranging from 0.03 to 0.12mg/ml and MIC90 values ranging from 0.06 to 0.25 mg/ml [1].
References:
[1] Milatovic D1, Schmitz FJ, Brisse S, Verhoef J, Fluit AC. In vitro activities of sitafloxacin (DU-6859a) and six other fluoroquinolones against 8,796 clinical bacterial isolates.Antimicrob Agents Chemother. 2000 Apr;44(4):1102-7.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 409.81 |
| Cas No. | 127254-12-0 |
| Formula | C19H18ClF2N3O3 |
| Solubility | insoluble in H2O; insoluble in DMSO; insoluble in EtOH |
| Chemical Name | 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | N[C@H](C1)C2(CC2)CN1c(c(Cl)c(c1c2)N([C@H](C3)[C@H]3F)C=C(C(O)=O)C1=O)c2F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
