SIN-1 chloride
Catalog No.
B5015
inhibitor of platelet aggregation
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SIN-1 chloride is an active metabolite of molsidomine, which is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions. SIN-1 decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[1,2].
References:
[1]. Rosenkranz B, Winkelmann B R, Parnham M J. Clinical pharmacokinetics of molsidomine. Clinical Pharmacokinetics, 1996, 30(5): 372-384.
[2]. Lomonosova E E, Kirsch M, Rauen U, et al. The critical role of hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide. Free Radical Biology & Medicine, 1998, 24(4): 522-528.
| Storage | Store at -20°C |
| M.Wt | 206.63 |
| Cas No. | 16142-27-1 |
| Formula | C6H11ClN4O2 |
| Solubility | Soluble to 100 mM in sterile water |
| Chemical Name | 5-imino-3-morpholino-5H-1,2,3-oxadiazol-3-ium-2-ide hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | N=C1O[N-][N+](N2CCOCC2)=C1.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
