Simvastatin (sodium salt)
Catalog No.
C4426
HMG-CoA reductase inhibitor
Featured Products
Simvastatin (sodium salt) (CAS: 101314-97-0) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a critical enzyme controlling the rate-limiting step in cholesterol biosynthesis. It binds with high affinity to HMG-CoA reductase, exhibiting a Ki of approximately 0.12 nM. In hepatocyte-derived Hep G2 cells, simvastatin demonstrated potent suppression of cholesterol biosynthesis, reducing the incorporation of radiolabeled acetate into sterols (IC50 ≈15 nM). Animal studies with orally administered simvastatin indicated marked reduction in plasma cholesterol levels, validating its utility in experimental models exploring cholesterol regulation and lipid metabolism.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 460.59 |
| Cas No. | 101314-97-0 |
| Formula | C25H41NaO6 |
| Synonyms | Zocor™ |
| Solubility | ≥28.85 mg/mL in DMSO; ≥23.05 mg/mL in EtOH; ≥5.47 mg/mL in H2O with ultrasonic |
| SDF | Download SDF |
| Canonical SMILES | C[C@H]1C=CC2=C[C@H](C)C[C@H](OC(C(C)(C)CC)=O)[C@]2([H])[C@H]1CC[C@@H](O)C[C@H](CC(O)=O)O.[NaH] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
