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Bioactive Compounds
Signaling Pathways

Signaling Pathways

A1769 KU-0060648
1 Citation

Target: PI3K|DNA-PK

Summary: Dual DNA-PK/PI3-K inhibitor, ATP-competitive
A2664 VX-661

Target: CFTR

Summary: F508del CFTR corrector

≥21.8 mg/mL
A1367 ALK-IN-1

Summary: Anaplastic lymphoma kinase (ALK) inhibitor

≥26.45 mg/mL
A1794 LY2835219

Target: Cyclin-Dependent Kinases

Summary: CDK4/6 inhibitor,potent and selective

≥30.15 mg/mL
A1720 Duvelisib (IPI-145, INK1197)

Target: PI3K

Summary: PI3K-δ/PI3K-γ inhibitor

≥20.84 mg/mL
A2547 Vortioxetine (Lu AA21004) HBr

Summary: 5-HT receptor modulator, antidepressant and anxiolytic

insoluble in H2O; ≥50 mg/mL
A2098 PRX-08066 Maleic acid

Summary: 5-HT2B receptor antagonist,potent and selective

Soluble in DMSO
A2308 TAK-438

Summary: Blocker of potassium-competitive acid

insoluble in H2O; insoluble in EtOH; ≥18.9 mg/mL
A8300 ZCL278
1 Citation

Target: Cdc42

Summary: Selective Cdc42 inhibitor

≥29.25 mg/mL
A8301 GW788388

Summary: ALK5 inhibitor, potent and selective

≥21.25 mg/mL