SEL120-34A hydrochloride
SEL120-34A hydrochloride (CAS No.: 1609452-30-3) is a highly selective ATP-competitive inhibitor of CDK8/CDK19.
In vitro, it exhibits IC₅₀ values of approximately 4.4 nM and 10.4 nM against CDK8/CycC and CDK19/CycC, respectively. It shows weak inhibition against other CDKs (1/2/4/5/6/7) and has a selectivity index of >200-fold over CDK9.
In cells, SEL120-34A inhibits the serine phosphorylation of STAT1-S727 and STAT5-S726, thereby affecting transcription elongation and the expression of inflammation- and tumor-associated genes.
SEL120-34A demonstrates significant anti-proliferative activity in a subset of AML cell lines with high STAT1/5 phosphorylation. It suppresses tumor growth, reduces leukemia burden, and shows favorable tolerability in acute myeloid leukemia xenograft models.
Accordingly, it is used as a representative molecule for targeted agents against the CDK8/CDK19-STAT axis in mechanistic and pharmacological studies.
| Storage | Store at -20°C |
| Cas No. | 1609452-30-3 |
| Formula | C15H18Br2N4•xHCl |
| Synonyms | Romaciclib hydrochloride |
| Chemical Name | 7,8-dibromo-9-methyl-2-(piperazin-1-yl)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | Cl.CC1=C(Br)C(Br)=C2CCCN3C(=NC1=C23)N1CCNCC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |