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SCH900776 S-isomer Checkpoint kinase(Chk)inhibitor

Catalog No.A3806
Size Price Stock Qty
5mg
$114.00
In stock
10mg
$188.00
In stock
20mg
$324.00
In stock
50mg
$606.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Chemical structure

SCH900776 S-isomer

SCH900776 S-isomer Dilution Calculator

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SCH900776 S-isomer Molarity Calculator

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Chemical Properties

Cas No. 891494-64-7 SDF Download SDF
Synonyms SCH 900776 S-isomer;SCH-900776 S-isomer
Chemical Name (S)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
Canonical SMILES NC1=C(Br)C([[email protected]@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
Formula C15H18BrN7 M.Wt 376.25
Solubility >37.6mg/ml in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM). SCH900776 exposure phenocopies short interfering RNA-mediated CHK1 ablation and interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in tumor cell backgrounds. Chk1 inhibitor SCH 900776 abrogates cytarabine-induced S-phase arrest and enhances cytarabine cytotoxicity in acute leukemia cell lines and leukemic blasts in vitro.