Saxagliptin Hydrochloride
Catalog No.
C8703
A selective, reversible dipeptidyl peptidase?4 (DPP?4) inhibitor
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Saxagliptin is a selective, reversible dipeptidyl peptidase‑4 (DPP‑4) inhibitor for type 2 diabetes. DPP‑4 normally rapidly degrades GLP‑1 and GIP; after inhibition, active circulating incretins increase, enhancing glucose‑dependent insulin secretion during meals while suppressing glucagon secretion from α cells and reducing hepatic glucose output, thereby improving fasting and postprandial blood glucose. Its main active metabolite, 5‑hydroxysaxagliptin, also has DPP‑4 inhibitory activity. Overall, it has a low risk of hypoglycemia, but large outcomes studies suggest a slight association with an increased risk of hospitalization for heart failure.
| Storage | 4℃, sealed storage, away from moisture and light |
| M.Wt | 351.88 |
| Cas No. | 709031-78-7 |
| Formula | C18H26ClN3O2 |
| Synonyms | BMS-477118 hydrochloride |
| Chemical Name | (1S,3S,5S)-2-((S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | Cl.[H][C@@]12C[C@]1([H])N([C@@H](C2)C#N)C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |