S2157
Catalog No.
BA3171
S2157, an N-alkylated trans-cyclopropylamine (TCP) derivative, is a potent lysine-specific demethylase 1 inhibitor.
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S2157, an N-alkylated trans-cyclopropylamine (TCP) derivative, is a potent inhibitor of lysine-specific demethylase 1.S2157 increases H3K9 methylation and corresponding H3K27 deacetylation in the super-enhancer region.S2157 inhibits transcription of the NOTCH3 and TAL1 genes, which induces TCP-resistant acute lymphoblastic leukemia T- ALL cells apoptosis.S2157 effectively crosses the blood-brain barrier and almost completely eradicates CNS leukemia in T-ALL cell transplanted mice.
| Physical Appearance | A solid |
| Storage | Tightly sealed and desiccated at 4°C |
| M.Wt | 451.94 |
| Cas No. | 2262488-39-9 |
| Formula | C23H28ClF2N3O2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |