(S)-(+)-Mandelic acid

(S)-(+)-Mandelic acid (CAS No.: 17199-29-0) is a chiral aromatic α-hydroxy acid belonging to the class of benzene and substituted derivatives, widely utilized as a biochemical reagent in life science research and drug discovery. As the optically active (S)-enantiomer of mandelic acid, this compound serves as a valuable model for studying stereoselective metabolism, enantiomeric interconversion, and chiral recognition processes, including its reported one-directional inversion to the (R)-enantiomer in preclinical animal models. It exhibits measurable affinity toward aldo-keto reductase family 1 member B1, with activity observed in the low micromolar range, supporting its relevance in investigations of enzymatic reduction pathways and metabolic enzyme modulation. (S)-(+)-Mandelic acid is commonly applied in in vitro assays to evaluate enzyme kinetics, stereospecific interactions, and redox-related biochemical mechanisms, as well as in cell-based systems examining metabolic processing and transport phenomena. In addition, it is employed as a reference standard or intermediate in the synthesis and resolution of chiral compounds, contributing to the development and screening of stereochemically defined molecules. Experimental concentrations and usage conditions vary depending on assay design, target system, and research objectives.