(S)-3-Aminoquinuclidine dihydrochloride

(S)-3-Aminoquinuclidine dihydrochloride (CAS No.: 119904-90-4) is a chiral quinuclidine-based amine widely utilized as a biochemical reagent and synthetic intermediate in life sciences and medicinal chemistry research. Characterized by its rigid bicyclic amine scaffold, this compound serves as a valuable building block for the construction of biologically active molecules and is frequently employed in the investigation of structure–activity relationships and ligand–target interactions. It is particularly relevant in studies of neurotransmitter systems, where quinuclidine derivatives are known to interact with neurotransmitter receptors, including cholinergic and other ligand-gated ion channels, as well as G protein-coupled receptors, typically exhibiting activity in the nanomolar to micromolar range depending on structural modifications. In addition, it can function as a reagent in derivatization reactions such as sulfonylation, facilitating the generation of compound libraries for drug discovery and chemical biology applications. This compound is commonly applied in in vitro receptor binding assays, cell-based functional studies, and early-stage pharmacological profiling, as well as in synthetic workflows aimed at developing novel probe molecules. Experimental concentrations and usage conditions vary according to specific assay systems and research objectives, underscoring its versatility as a tool compound in neuroscience, receptor biology, and medicinal chemistry research.