RGD Peptide

RGD Peptide (CAS No.: 114681-65-1) is a synthetic short peptide corresponding to the GRGDNP sequence, widely utilized as a biochemical tool for investigating integrin-mediated cell signaling and adhesion processes. As a competitive inhibitor of integrin–ligand interactions, it primarily targets integrin α5β1 and disrupts its binding to extracellular matrix components, thereby modulating cell–ECM interactions that are essential for cellular adhesion, migration, proliferation, and differentiation. Mechanistically, this peptide interferes with integrin signaling cascades and has been shown to promote apoptosis through induction of conformational changes in pro-caspase-3, facilitating its activation and subsequent proteolytic processing. In vitro studies commonly employ this peptide at concentrations in the nanomolar to micromolar range, depending on cell type and experimental design, to dissect integrin-dependent pathways and cytoskeletal dynamics. RGD Peptide is broadly applied in cell-based assays, adhesion and migration studies, and the evaluation of integrin-targeted inhibitors, as well as in model systems examining tumor cell behavior, angiogenesis, and extracellular matrix remodeling, with experimental dosing and conditions tailored to specific research objectives.