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Recombinant Murine gamma-Interferon Inducible Protein 10/CXCL10

Catalog No.
P1488
 
Grouped product items
SizePriceStock Qty
5ug
$99.00
Ship with 5-10 days
100ug
$813.00
Ship with 5-10 days
500ug
$1,825.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene, and in murine it is also named the CRG-2 gene. The gene was originally identified as an immediate early gene induced in response to macrophage activation. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages. It also has other roles, such aspromotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis. Murine CXCL10 shares approximately 67 % amino acid sequence identity with human CXCL10.

Reference

1. Luster AD, Unkeless JC, Ravetch JV. 1985. Nature. 315:672-6

2. Luster AD, Jhanwar SC, Chaganti RS, et al. 1987. Proc Natl Acad Sci U S A. 84:2868-71

3. Vanguri P, Farber JM. 1990. J Biol Chem. 265:15049-57

4. Booth V, Keizer DW, Kamphuis MB, et al. 2002. Biochemistry. 41:10418-25

5. Dufour JH, Dziejman M, Liu MT, et al. 2002. J Immunol. 168:3195-204

6. Angiolillo AL, Sgadari C, Taub DD, et al. 1995. J Exp Med. 182:155-62.

Information

Gene ID15945
Accession #P17515
Alternate NamesGamma-IP10, Small-inducible Cytokine B10, C7, Interferon-gamma Induced Protein CRG-2
SourceEscherichia coli.
M.WtApproximately 8.7 kDa, a single non-glycosylated polypeptide chain containing 77 amino acids.
AA SequenceIPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP
AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
Stability & StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
FormulationLyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH 7.4.
ReconstitutionWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Biological ActivityFully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human peripheral blood lymphocytes is in a concentration range of 0.1-10.0 ng/ml in the presence of IL-2.
Shipping ConditionGel pack.
HandlingCentrifuge the vial prior to opening.
UsageFor Research Use Only! Not to be used in humans.

Quality Control

Quality Control & DataSheet

View current batch:
    Purity > 97 % by SDS-PAGE and HPLC analyses.
    Endotoxin: Less than 1 EU/μg of rMuIP-10/CXCL10 as determined by LAL method.
  • Datasheet