Recombinant Mouse IL-4 (His, Strep)

Interleukin 4 (IL-4), also known as B cell stimulating factor-1, is a monomeric Th2 cytokine that exhibits pleiotropy in the immune response. The amino acid sequence homology of mature mouse IL-4 was 39%, 39% and 59% with bovine, human and rat IL-4, respectively. IL-4 activity in human, mouse, and rat is species-specific. IL-4 functions through two receptor complexes. Type I receptors expressed on hematopoietic cells are ligand-bound IL-4Rα and common γ heterodimers. Type II receptors on non-hematopoietic cells are composed of IL-4Rα and IL-13Rα1. Type II receptors also transmit IL-13-mediated signaling. IL-4 is predominantly expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It can promote the proliferation and survival of mouse B cells and the conversion of immunoglobulins to IgG1 and IgE, promote the acquisition of Th2 phenotype by na?ve CD4+ T cells, promote the initiation and chemotaxis of mast cells, eosinophils and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a leading role in the occurrence and development of allergic inflammation and asthma.