Recombinant Human IFN-alpha B2/IFNA8 Protein (His, Flag)

Human interferon alpha-8 (Interferon alpha-8, abbreviated as IFN-α-8, also known as interferon alpha-B/LeIF B and interferon alpha-B2) is a type I interferon cytokine encoded by the IFNA8 gene and primarily produced by macrophages. Functionally, interferon alpha-8 exerts its core antiviral effects by stimulating the production of protein kinase and oligoadenylate synthetase. It is also broadly involved in various biological processes, including adaptive immunity, humoral immunity, defense response to viruses, and the activation of B cells, T cells, and natural killer cells, thereby mediating the type I interferon signaling pathway. Furthermore, this protein directly interacts with GPR152 and serves as a component of the interferon alpha receptor-ligand complex (CPX-6001). In basic research, it serves as a model protein for studying antiviral immune mechanisms, and its recombinant form holds significant application value in the development of drugs for treating specific viral infections and tumors.