Recombinant Caprine IL-9 (N-His)

Goat interleukin-9 (Capra hircus Interleukin-9, Goat IL-9) is a secreted pleiotropic cytokine belonging to the IL-7/IL-9 family, functioning as both an immunomodulatory cytokine and a growth factor. It is produced mainly by activated CD4+ T cells (especially Th9 cells), Th2 cells, group 2 innate lymphoid cells (ILC2), mast cells, and eosinophils, and is secreted into the extracellular space via a signal peptide (subcellular localization: Secreted). It acts through a receptor complex composed of IL-9Rα and the γc chain, activating the JAK1/JAK3-STAT signaling pathway. Functionally, goat IL-9 promotes T cell proliferation, enhances IgE production by B cells, promotes mast cell growth and differentiation, induces mucin production and chemokine release in airway epithelial cells, and plays a key role in allergic diseases and anti-parasitic immunity.