Raphin1
Catalog No.
BA8148
Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B.
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Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B.Raphin1 binds strongly to the R15B-PP1c holophosphatase (=33nM) and binds R15B-PP1c approximately 30-fold more selectively compared to R15A-PP1c.Raphin1 crosses the blood-brain barrier and reduces protein error biological and molecular defects in a mouse model of folding disease.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 231.08 |
| Cas No. | 2022961-17-5 |
| Formula | C8H8Cl2N4 |
| Solubility | ≥8.68 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O |
| Chemical Name | (E)-2-(2,3-dichlorobenzylidene)hydrazine-1-carboximidamide |
| SDF | Download SDF |
| Canonical SMILES | ClC1=C(Cl)C(/C=N/NC(N)=N)=CC=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
