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(R,S)-Anatabine (tartrate)

Catalog No.
C4888
Aβ inhibitor
Grouped product items
SizePriceStock Qty
5mg
$102.00
Ship with 5-10 days
10mg
$183.00
Ship with 5-10 days
50mg
$813.00
Ship with 5-10 days
100mg
$1,422.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers and eggplants [1]. Anatabine is an Aβ inhibitor [1]. (R,S)-Anatabine (tartrate) is preferable to (R,S)-Anatabine for certain applications and formulations.

Aβ peptides play a dominant role in the development of Alzheimer's disease. Natural soluble Aβ oligomers and more specifically Aβ dimers isolated from Alzheimer's disease brains have been involved in inducing tau hyperphosphorylation and neuritic degeneration, which results in the accumulation of Aβ oligomers to the neurofibrillary degeneration observed in Alzheimer's disease (AD) [1].

In vitro: Anatabine dose-dependently lowered Aβ1-40 and Aβ1-42 levels and reduced sAPPβ production without any effects on sAPPα levels. Anatabine lowered Aβ production by mainly impacting the β-cleavage of APP. Anatabine lowered NFκB activation. Anatabine inhibited BACE-1 transcription and reduced BACE-1 protein levels in human neuronal like SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation [1].

In vivo: In a transgenic mouse model with AD, treatment with anatabine for 4 days remarkably lowered brain soluble Aβ1-40 and Aβ1-42 levels [1].

Reference:
[1] Paris D, Beaulieu-Abdelahad D, Bachmeier C, et al.  Anatabine lowers Alzheimer's Aβ production in vitro and in vivo[J]. European journal of pharmacology, 2011, 670(2): 384-391.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt310.3
FormulaC10H12O2·C4H6O6
Solubility≤1mg/ml in ethanol;20mg/ml in DMSO;33mg/ml in dimethyl formamide
Chemical Name1,2,3,6-tetrahydro-2,3'-bipyridine 2,3-dihydroxysuccinate
SDFDownload SDF
Canonical SMILESOC(C(O)C(O)=O)C(O)=O.C1(C2=CN=CC=C2)CC=CCN1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

(R,S)-Anatabine (tartrate)